,453 Unsubscribe from sharma at subject webmail kamagra canada buy online sharma keep us up to date on fast delivery mail order kamagra last seen: monday, 09-jul-2020, 12:14 am. dermatologistsIn the context of understanding the metabolic consequences of major life style changes, the major focus of our research is on the long-term effects of dietary and calorie restriction. In contrast to the short-term effects of these dietary and caloric interventions, the long-term consequences on energy balance and its regulation is poorly understood. Calorie restriction is a potent intervention for increasing life span and has been shown to protect against a variety of degenerative and cancerous diseases in several species. Recent data from our laboratory suggests that calorie restriction may also have the ability to protect against other age related disease states including the diabetic complications associated with type II diabetes. The mechanism for the protection is likely to be related to the ability of calorie restriction to maintain a state of reduced energy that is also associated with increased resistance to oxidant injury. As a result, calorie restriction, perhaps surprisingly, does not reduce either tissue oxidation or production of reactive oxygen species (ROS) in several tissues. As a consequence, the acute mechanisms for protecting against oxidative injury may differ significantly from the chronic adaptations in metabolism that promote longevity. Thus, the overall goal of this proposal is to investigate the effects of calorie restriction in several tissues and the overall impact on redox status and the ability to adapt to oxidative stress. In addition, we also wish to establish whether age related changes in redox status contribute to the development of diabetes associated complications and evaluate the use of dietary antioxidants to prevent and treat diabetes and diabetic complications. To achieve this goal we will undertake four specific aims: 1) Evaluate the impact of calorie restriction on oxidant injury and antioxidant levels in several tissues including the brain, pancreas and aorta in normal and diabetic rats. 2) Determine whether calorie restriction alters the profile of oxidant injury and antioxidant defenses in an age and species dependent manner. 3) Assess the impact of long-term calorie restriction on redox status, oxidative stress and antioxidant defenses in tissues during aging. 4) Evaluate the effect of age, type II diabetes and calorie restriction on redox status and the development of oxidative stress in tissues. Results obtained from these studies will establish the impact of calorie restriction on
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